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CoronaVirus Infections (Bacterial and Viral) Viruses

All You Need to Know About Gilead’s Remdesivir! A Hype Or a Real Solution?

An experimental drug called Gilead’s Remdesivir produced by Gilead Sciences gives us hope. But is it a real solution that gives us chances to finally put an end to this tremendous world-spread experience of the pandemic? Or is it just a momentary hype like many others? With the questionable safety of hydroxychloroquine (although the drug was so enthusiastically welcomed by President Donald Trump), it’s doubtful to ever call this one an appropriate drug-fighter against COVID-19. In those circumstances, with no national plan B whatsoever, Remeesivir comes into action, and its creators, slowly but surely become heroes. What can recent studies tell us about the prospective treatments for this deadly disease?

All You Need to Know About Gilead’s Remdesivir! A Hype Or a Real Solution?

What is Remdesivir, and where does it come from?

Gilead’s Remdesivir is an antiviral medication developed by the American biopharmaceutical company Gilead Sciences. It’s being studied as a possible post-infection treatment for COVID-19. Recently, the company published an analysis in the New England Journal of Medicine tracking the responses of 53 patients with severe cases of COVID-19 to Remdesivir therapy. Patients were given the unapproved drug because no other options were available. According to the report, doctors observed clinical improvement in 36 of the 53 patients; eight got worse, and seven died. Doctors were able to take 17 of the 30 patients who were on ventilators, life-support devices that help people breathe, off the machines.

More about Remdesivir as a drug

Remdesivir is a nucleotide analog, specifically an adenosine analog, which inserts into viral RNA chains, causing their premature termination. It was created and developed as a treatment for Ebola virus disease and Marburg virus infections. Gilead Sciences subsequently discovered that Gilead’s Remdesivir had antiviral activity in vitro against multiple filo-, pneumo-, paramyxo-, and coronaviruses. In January 2020, Gilead began laboratory testing of Remdesivir against SARS-CoV-2, stating that Remdesivir was active against SARS and MERS in animal models. A small trial of Remdesivir in rhesus macaque monkeys with COVID-19 infections found that it prevents disease progression. On 21 January 2020, the Wuhan Institute of Virology applied for a Chinese “use patent” on Remdesivir, for the novel use of treating COVID-19.

Current affairs with Remdesivir 

The authors of the study note that the death rate of the patients they observed — 13 percent — is lower than the death rate of 17 to 78 percent in China among people who are severely ill with COVID-19. Side effects included diarrhea, rash, renal impairment, and hypotension. Around the same time, Chinese medical researchers reported that Remdesivir seemed to have “fairly good inhibitory effects” on SARS-CoV-2, after which requests to begin clinical testing were submitted.

On 6 February 2020, a clinical trial of Gilead’s Remdesivir began in China. On 18 March 2020, the WHO announced the launch of a four-arm pragmatic clinical trial (SOLIDARITY trial) that would include one group of patients treated with Remdesivir. While a cohort study published in April 2020 saw possible improvement, determining whether or not the medication is effective is going to require a randomized controlled trial. As of April 2020, Remdesivir is viewed as the most promising treatment for COVID-19, and there are at least seven separate clinical trials underway or planned.

Limitations and concerns linked to Remdesivir 

There are limitations on what conclusions can be drawn from the recent analysis. There was no randomized control group, which would have allowed to compare how patients given a placebo performed relative to those given Remdesivir. The total number of patients, spread out across the United States, Canada, Europe, and Japan, is still very small. But the authors of the study, and outside experts, have described the results as a reason to have hope. “We cannot draw definitive conclusions from these data, but the observations from this group of hospitalized patients who received Remdesivir are hopeful” – says Jonathan Grein, director of hospital epidemiology at Cedars-Sinai Medical Center in Los Angeles, in a statement from Gilead – “We look forward to the results of controlled clinical trials to potentially validate these findings”.

Eric Feigl-Ding, an epidemiologist and health economist at the Harvard T. H. Chan School of Public Health tweeted “TRIALS TRIALS TRIALS PLEASE”. Paul Goepfert, an infectious disease specialist at the University of Alabama at Birmingham, claims that “it’s a promising drug, but it doesn’t definitively prove anything. […] The main thing you can gather from this study is that it doesn’t cause any untoward harm”.

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Health News Liver Cancer

She Was Dying of Liver Cancer But a Hepatitis C-infected Organ Saved Her Life

Betty Huart had liver cancer, and she needed a transplant. However, a hepatitis C-infected organ was the only option. Why would a doctor implant a hepatitis C-infected liver in someone who was already fighting for their life?  

She Was Dying of Liver Cancer But a Hepatitis C-infected Organ Saved Her Life

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Stepping into Uncharted Waters

The practice of medicine is just that, a practice. When Dr. James Burton broke the Hippocratic Oath to “do no harm,” he knew he was walking into uncharted territories. The demand for livers and kidneys in the United States is at astronomical levels. However, there are more livers available than ever before. 

Some estimate that it’s due to the opioid crisis. The only problem with these organs is that they are often infected with things like hepatitis C. Liver cancer is almost always deadly, but other conditions are treatable. 

Treatments for hepatitis have been groundbreaking in the past decade. Most people are cured within a couple of months. Dr. Burton knew that a diseased liver was better than no liver at all. Cancer would have killed her quickly if they did nothing. He wasn’t the first doctor to try such a radical approach. This maneuver was successfully completed in 2015 by John Hopkins Hospital. 

A Diseased Liver Was the Best Option

Huart agreed to the risky surgery, and in 2017, Brigham and Women’s Hospital in Boston did the transplant. Her case is a success story as it took two weeks to clear hepatitis C from her transplanted liver. As anticipated, the antiviral drug treatment work. Without this diseased liver, she may not be alive today. 

The American Liver Foundation estimates that more than 17,000 people are waiting for a liver transplant in this country. About 6,000 people get their miracle transplant each year. At 66 years of age, Huart waited several months for a new liver. Her situation was common. It started as fatty liver disease, morphed into cirrhosis, and then finally developed into cancer. A transplant was her only option to live. 

When she got the phone call on March 12, 2019, she was less than optimistic. Being advised that she was going to be part of a groundbreaking trial to save her life was scary. Her husband almost died from hepatitis C years ago. 

New Hope for Those Suffering from Liver Disease

The surgery went off without a hitch. Denver was in the middle of one of the worst snowstorms of the year, but the medical team didn’t let the weather stop them. As the doctors’ feared, Huart had contracted hepatitis within a few days, but she was treated and cured.

There are no more studies needed regarding hepatitis C-infected organ transplants. It’s now becoming standard treatment when all hope is lost. All the influx of diseased livers can be used to help people like Huart, who have no options left.

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health infectious diseases natural remedies Signs and Symptoms

This is How You Can Treat Bronchitis and STOP Painful Coughing Attacks

There are several natural and inexpensive ways to treat bronchitis. Bronchitis refers to an inflammation of the lining of bronchial tubes which deliver air to and from your lungs. Patients with bronchitis repeatedly cough up thickened mucus, which can be discolored sometimes. Bronchitis can either be chronic or acute. The chronic type manifests as frequent bouts of bronchitis, which requires medical assistance. Acute bronchitis usually improves within a few days and does not trigger lasting effects. In some cases, you can continue coughing for weeks even when on medication to treat bronchitis.

This is How You Can Treat Bronchitis and STOP Painful Coughing Attacks.

Signs and Symptoms of Bronchitis

If you have chronic or acute bronchitis, symptoms and signs may include:

1. Frequent coughs
2. Chest discomforts
3. Sputum (mucus) which may be yellowish-grey, whitish, or green. In rare cases, the sputum may be streaked with blood.
4. Shortness of breath or wheezing
5. Mild fevers and chills
6. Fatigue

Bronchitis Risk Factors

The following factors can put you at an increased risk of contracting bronchitis:

1. Smoking: If you smoke or stay with a smoker, you are at higher risk of contracting chronic or acute bronchitis. Quitting the habit can help to prevent and treat bronchitis.
2. Exposure to irritants: You are more likely to develop bronchitis if you live or work in an area with lung irritants. These include chemical fumes, grains, and textiles.
3. Decreased immunity: This can be as a result of another acute disease like cold, or a condition that weakens your immune system
4. Gastric reflux: Frequent bouts of severe heartburn may irritate your throat and make you vulnerable to bronchitis attack.

Natural Remedies to treat Bronchitis

1. Honey

One of the best natural ways to treat bronchitis cough is through the use of honey. It has antiviral and antibacterial properties that soothe the throat. Additionally, honey boosts the immune system.

• You can add a teaspoon of honey to your regular cup of tea or coffee.
• Alternatively, you can mix honey with a warm cup of lemon water to deal with congestion and inflammation that come with bronchitis.

2. Ginger

Ginger is commonly used for fighting the common cold, but can also help to treat bronchitis. It has immune-boosting and anti-inflammatory properties that help to relieve swollen, irritated, or inflamed bronchial tubes.

• Mix half a teaspoon of ground ginger with cinnamon and cloves in a cup of hot water. Stir thoroughly and take the mixture a couple of days to treat bronchitis.
• You can also prepare a herbal tea by adding a teaspoon of ginger powder and black pepper to a cup of hot water. Allow it to steep for a few minutes and add some honey. Take it twice every day.
• Another option is to combine a teaspoon of ginger, cloves, and pepper. Drink it three times a day with milk or honey.

3. Eucalyptus Oil

If you want to treat bronchitis, steam therapy with eucalyptus oil can be very helpful. Eucalyptus oil softens the mucous in your blocked airways. It has antibacterial properties that will enhance the curing process.

• Take a few drops of eucalyptus oil and add it to a bowl of boiling water. Cover your head with a towel in order to inhale the steam. You can use tea tree oil or pine oil if you don’t have eucalyptus oil.
• You can also apply eucalyptus oil externally on your chest. This will assist in expelling the mucous and improve your respiratory function.

4. Onion

Onions have expectorant properties that help in dissolving the mucus and phlegm. Additionally, the onion juice will prevent further build up of mucus, which helps to treat bronchitis.

Related Link: DIY Homemade Onion Juice and Honey Hair Loss Treatment

• Simply take a teaspoon of raw onion juice in the morning before taking your breakfast.
• You can also use raw onions in your salad or add onion when cooking.

5. Garlic

Credit to its antiviral and an antibiotic property, garlic is quite an inexpensive home remedy that can help to treat bronchitis.

• Peel and chop three garlic cloves
• Boil them in a glass of milk
• Drink every night before retiring to bed.

6. Turmeric

The anti-inflammatory properties of turmeric have been shown to be ideal for treating the coughs related to bronchitis. It also has an expectorant effect which deals with mucus to provide relief.

• Boil a teaspoon of turmeric powder in a glass of milk
• Take it twice or thrice every day.

Note: You should not use turmeric to treat bronchitis if you suffer from hyperacidity, gallbladder stones, obstructive jaundice, or stomach ulcers.

7. Epsom Salt

You can get relief from bronchitis symptoms by taking an Epsom salt bath.

• Add 2 pounds of Epsom salt to warm bath water
• Stir it until it is fully dissolved.
• Immerse yourself in the bath for 30 minutes
• Repeat twice every week if you have acute bronchitis. To treat chronic bronchitis, you can repeat it daily or every other day.

Conclusion

Bronchitis is a viral disease that can be easily contracted by anyone. The best way to treat bronchitis is by dealing with its symptoms, especially the recurrent coughs. The frequent coughs associated with bronchitis can be disturbing. If you are suffering from bronchitis, the above natural ways can stop the painful cough attacks. You should contact a doctor if your symptoms don’t improve with these natural remedies

Categories
Health Benefits of Foods Liver

How These 10 Herbs Promote Healthy Liver Function

How These 10 Herbs Promote Healthy Liver Function

The liver is one of the body’s vital organs. In a nutshell, the liver is our filter bag: it stops the bad stuff from going in. Like the air filter in a car, its function can become compromised. Most of us tax our liver and other organs with a Western diet typically high in sodium, sugar, fat and cholesterol. For many people, alcohol and tobacco for are particularly potent and toxic mix.

Fortunately, nature has our backs if we care to listen. There’s a convenient menu of herbs your liver will thank you for. Add these herbs to your daily diet as spices and flavorings or take them in supplement form.

Artichoke

A bile clog within the liver can be most unpleasant. The leaf of this herb enhances bile flow.

Astragalus

A staple in Chinese herb medicine, this herb possesses antiviral and immune-boosting properties. Saponin is a chemical compound intrinsic to astragalus that aids the liver against chemical-caused damage.

Borotutu Bark

This ancient herb helps stop liver damage with its antioxidant arsenal. It’s good for the stomach and GI tract, too.

Dandelion

Dandelion is available in capsule form. Dandelion extract can be used as a tea. Studies demonstrate that dandelion treats swelling of the liver and promotes proper bile function.

Garlic

Garlic is another comprehensive detox, agent. It aids the immune system and benefits the liver with its rich sulfur content. Sulfur is required to activate the liver’s enzymes that sweep it free of toxins like a push-broom. Garlic is best consumed raw so its compounds are not destroyed. Garlic is a common cooking ingredient. Garlic capsules and soft gels are sold in any pharmacy.

RELATED ARTICLE: 5 Signs Of Impaired Liver Detox

Greater Celandine

A detox herb and bile facilitator, this herb is rich in alkaloids and antioxidants.

Milk Thistle

Milk thistle is another supplement-ready herb upheld as the most potent of liver aids. Its power lies in a compound called silymarin, which acts as the proverbial sword against toxins that damage the liver. People who drink and smoke should take milk thistle regularly.

Peppermint

This is a pleasant, great-tasting herb popularly marketed as a tea. It opens up bile ducts and breaks down fats.

Turmeric

Another common spice and bile-promoting agent, turmeric cannot be recommended enough for its superior ability as an anti-inflammatory.

Yellow Dock Root

This acts similarly to peppermint in the breakdown of fats. It also helps to prompt bile production.

As always, we have the know-how. The question is: do we use that knowledge and turn it into a to-do, or ignore it and continue to tax our body to its limits? If we have the resources, the herbs listed are inexpensive, why not use them?

Categories
Health Benefits of Foods live longer

Bioflavonoids

Bioflavonoids

Bioflavonoids were originally called vitamin P, and they are also known as flavones. They accompany vitamin C in natural foods, and are responsible for the color in the leaves, flowers, and stems of food plants. Their primary job in the body is to protect the capillaries, to keep them strong and to prevent bleeding. Bioflavonoids are also anti-inflammatory. Many of the medicinally active substances contained in herbs are bioflavonoids, which can be found in many sources such as: citrus fruits, apricots, cherries, green peppers, broccoli, and lemons. The central white core of citrus fruits is the richest source.

health benefits of bioflavonoids

Bioflavonoids properties:
* Reduce bruising in susceptible individuals
* Protect capillaries
* Protect against cerebral and other hemorrhaging
* Reduce bleeding during menstruation
* Antioxidant and encourage the antioxidant qualities of vitamin C
* Antiviral activity
* Anti-inflammatory
* May help to cure colds

From: Natural Remedies for Healthy Living , The Readers Digest Association,2011

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